反应详情

2-Chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoic acid hydrochloride (D35) (0.20 g) was dissolved in thionyl chloride (10 ml) and heated under reflux for 1.5 h. The thionyl chloride was removed by evaporation and the residue evaporated from DCM (3×10 ml) to give the title compound (D36) (0.21 g).

1. temperatureheated
2. temperatureunder reflux for 1.5 h
3. customThe thionyl chloride was removed by evaporation
4. customthe residue evaporated from DCM (3×10 ml)