HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoic acid hydrochloride → 2-Chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl chloride hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoic acid hydrochloride | HCID 68966010 | — |
| Solvent | Thionyl Chloride | HCID 24386 | — |
| Product | 2-Chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoyl chloride hydrochloride | HCID 17986252 | 199.4% |
Reaction Steps
2-Chloro-4-[(1-cyclobutyl-4-piperidinyl)oxy]benzoic acid hydrochloride (D35) (0.20 g) was dissolved in thionyl chloride (10 ml) and heated under reflux for 1.5 h. The thionyl chloride was removed by evaporation and the residue evaporated from DCM (3×10 ml) to give the title compound (D36) (0.21 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446103B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-c5f30595da3345ba8bea3dcbfe2d3aee |
| Source note | uspto-grants-2008_11 |