[3-(1H-Indol-7-yl)-3-phenyl-propyl]-methyl-amine → Hydrochloric Acid

HRID 268784Notes

Reaction equation

HRID 268784 reaction equation
[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH:10]([C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][CH:17]=3)[CH2:11][C:12]([NH:14][CH3:15])=O)[CH:8]=2)[CH:3]=[CH:2]1.N1C2C(=CC=CC=2C(C2C=CC=CC=2)CCNC)C=C1>>[ClH:22].[NH:1]1[C:9]2[C:4](=[CH:5][CH:6]=[C:7]([CH:10]([C:16]3[CH:17]=[CH:18][C:19]([Cl:22])=[CH:20][CH:21]=3)[CH2:11][CH2:12][NH:14][CH3:15])[CH:8]=2)[CH:3]=[CH:2]1

Participants

4

Reactant 2

HCID 17747555[3-(1H-Indol-7-yl)-3-phenyl-propyl]-methyl-amineHCID 59831641HCID 59831641, compound

Product 2

HCID 313Hydrochloric AcidYield 92%HCID 59831798HCID 59831798, compound

Procedure

[3-(1H-Indol-6-yl)-3-(4-chloro-phenyl)-propyl]-methyl-amine XLV was prepared as a hydrochloride (240 mg, 92% yield) from 3-(1H-indol-6-yl)-3-(4-chloro-phenyl)-N-methyl-propionamide, using the procedure described for [3-(1H-indol-7-yl)-3-phenyl-propyl]-methyl-amine XX (see Example 4). MS (M+H)=299.

Sources & evidence

ORD record
ord-95f18a594b0f419ebacedca650a19c89
Source dataset
uspto-grants-2008_11
Patent number
US07446118B2

Reaction notes

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