5-Bromoindole → 5-Bromo-3-cyanoindole

HRID 268795Notes

Reaction equation

[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.BrC1C=CC=C2C=1C(C#N)=[CH:15][NH:16]2>>[Br:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[C:15]#[N:16]

Participants

Reactant 2

HCID 249055-Bromoindole

HCID 27632324-Bromo-1H-indole-3-carbonitrile

Product 1

HCID 36233545-Bromo-3-cyanoindoleYield 66%

Procedure

5-Bromo-1H-indole-3-carbonitrile LXII (3.72 g, 66% yield) was prepared from 5-bromo-indole using the procedure described for 4-bromo-1H-indole-3-carbonitrile LVII (see Example 14).

Sources & evidence

ORD record: ord-5ae5ea2dc3824f19a048b99f71002442
Source dataset: uspto-grants-2008_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07446118B2

Reaction notes

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