3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester → N-Methyl-3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylamide

HRID 268830노트

반응식

HRID 268830 반응식
C(O[C:4](=[O:23])[CH:5]=[C:6]([C:13]1[CH:21]=[C:20]2[C:16]([CH:17]=[CH:18][N:19]2[CH3:22])=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)C.C(OC(=O)C=C(C1C=CC=C2C=1C(C#N)=[CH:39][NH:40]2)C1C=CC=CC=1)C>>[CH3:39][NH:40][C:4](=[O:23])[CH:5]=[C:6]([C:13]1[CH:21]=[C:20]2[C:16]([CH:17]=[CH:18][N:19]2[CH3:22])=[CH:15][CH:14]=1)[C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1

참가 물질

3

반응물 2

HCID 673550473-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl esterHCID 673553223-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester

생성물 1

HCID 67355247N-Methyl-3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylamide

실험 절차

N-Methyl-3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylamide CXLIV was prepared from 3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester using the procedure described above for preparation of 3-(1H-Indol-7-yl)-N-methyl-3-phenyl-acrylamide XVIII (see Example 4).

출처 및 근거

ORD 기록
ord-cd6aea76735d42c8bee3482b8ce035fa
출처 데이터셋
uspto-grants-2008_11
특허 번호
US07446118B2

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