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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 268830Generated: October 26, 2026

3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester → N-Methyl-3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylamide

https://huagongshe.com/reaction/268830

Reaction equation

Participants

RoleNameHCIDCharge
Reactant3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355047—
Reactant3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355322—
ProductN-Methyl-3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylamideHCID 67355247—

Reaction Steps

N-Methyl-3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylamide CXLIV was prepared from 3-(1-methyl-1H-indol-6-yl)-3-phenyl-acrylic acid ethyl ester using the procedure described above for preparation of 3-(1H-Indol-7-yl)-N-methyl-3-phenyl-acrylamide XVIII (see Example 4).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07446118B2
Source datasetuspto-grants-2008_11
ORD IDord-cd6aea76735d42c8bee3482b8ce035fa
Source noteuspto-grants-2008_11