Ethyl 3-(pyridin-2-yl)acrylate → 3-(5-Methoxy-1H-indol-7-yl)-3-phenyl-acrylic acid ethyl ester
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:9](=[C:10](Br)[CH:11]=1)[NH:8][CH:7]=[CH:6]2.C(OC(=O)C=CC1C=CC=CN=1)C.[CH2:26]([O:28][C:29](=[O:49])[CH:30]=[C:31](C1C=CC=C2C=1C(C#N)=CN2)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH3:27]>>[CH2:26]([O:28][C:29](=[O:49])[CH:30]=[C:31]([C:10]1[CH:11]=[C:3]([O:2][CH3:1])[CH:4]=[C:5]2[C:9]=1[NH:8][CH:7]=[CH:6]2)[C:32]1[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=1)[CH3:27]Participants
4
Procedure
3-(5-Methoxy-1H-indol-7-yl)-3-phenyl-acrylic acid ethyl ester CLXXIX was prepared from 5-methoxy-7-bromo-1H-indole and 3-pyridin-2-yl-acrylic acid ethyl ester using the procedure described for preparation of 3-(3-Cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII (Example 14).
Sources & evidence
- ORD record
- ord-519daf2ab6f34febb8a986520681fa95
- Source dataset
- uspto-grants-2008_11
- Patent number
- US07446118B2
Reaction notes
Loading…