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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 268849Generated: October 30, 2026

Ethyl 3-(pyridin-2-yl)acrylate → 3-(5-Methoxy-1H-indol-7-yl)-3-phenyl-acrylic acid ethyl ester

https://huagongshe.com/reaction/268849

Reaction equation

Participants

RoleNameHCIDCharge
ReactantEthyl 3-(pyridin-2-yl)acrylateHCID 370265—
Reactant7-Bromo-5-methoxy-1H-indoleHCID 19804160—
Reactant3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 67355322—
Product3-(5-Methoxy-1H-indol-7-yl)-3-phenyl-acrylic acid ethyl esterHCID 67356599—

Reaction Steps

3-(5-Methoxy-1H-indol-7-yl)-3-phenyl-acrylic acid ethyl ester CLXXIX was prepared from 5-methoxy-7-bromo-1H-indole and 3-pyridin-2-yl-acrylic acid ethyl ester using the procedure described for preparation of 3-(3-Cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII (Example 14).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07446118B2
Source datasetuspto-grants-2008_11
ORD IDord-519daf2ab6f34febb8a986520681fa95
Source noteuspto-grants-2008_11