3-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester → 3-(3-methyl-1H-indazol-5-yl)-3-phenyl-acrylic acid ethyl ester

HRID 268872Notes

Reaction equation

HRID 268872 reaction equation
[CH3:1][C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[C:8](Br)[CH:9]=2)[NH:4][N:3]=1.[CH2:12]([O:14][C:15](=[O:35])[CH:16]=[C:17](C1C=CC=C2C=1C(C#N)=CN2)[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:13]>>[CH2:12]([O:14][C:15](=[O:35])[CH:16]=[C:17]([C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[NH:4][N:3]=[C:2]2[CH3:1])[C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1)[CH3:13]

Participants

3

Reactant 2

HCID 673553223-(3-cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl esterHCID 178434225HCID 178434225, compound

Product 1

HCID 1784708683-(3-methyl-1H-indazol-5-yl)-3-phenyl-acrylic acid ethyl ester

Procedure

3-(3-Methyl-1H-indazol-5-yl)-3-phenyl-acrylic acid ethyl ester CCXIX) was prepared from 3-methyl-5-bromo-1H-indazole using the procedure described for preparation of 3-(3-Cyano-1H-Indol-4-yl)-3-phenyl-acrylic acid ethyl ester LVIII (Example 14).

Sources & evidence

ORD record
ord-2ecaf6b4fb2e403b85b3e5b25f1f085e
Source dataset
uspto-grants-2008_11
Patent number
US07446118B2

Reaction notes

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