Trifluoroacetic acid → HCID 59831807, compound

HRID 268892Notes

Reaction equation

HRID 268892 reaction equation
[CH3:1][O:2][C:3]1[C:11]2[C:6](=[CH:7][C:8]([CH:12]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[N:19]=3)[CH2:13][C:14]([NH:16][CH3:17])=O)=[CH:9][CH:10]=2)[NH:5][N:4]=1.C(O)(C(F)(F)F)=O.N1C2C(=CC=CC=2C(C2C=CC=CC=2)CCNC)C=C1>>[CH3:1][O:2][C:3]1[C:11]2[C:6](=[CH:7][C:8]([CH:12]([C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[N:19]=3)[CH2:13][CH2:14][NH:16][CH3:17])=[CH:9][CH:10]=2)[NH:5][N:4]=1

Participants

4

Reactant 3

HCID 6422Trifluoroacetic acidHCID 17747555[3-(1H-Indol-7-yl)-3-phenyl-propyl]-methyl-amineHCID 59831789HCID 59831789, compound

Product 1

HCID 59831807HCID 59831807, compound

Procedure

[3-(3-Methoxy-1H-indazol-6-yl)-3-(6-methyl-pyridin-2yl)-propyl]-methyl-amine CCXLVI was prepared from 3-(3-methoxy-1H-indazol-6-yl)-N-methyl-3-(6-methyl-pyridin-2yl)-propionamide and TFA as a bis-trifluoroacetate using the procedure described for preparation of [3-(1H-Indol-7-yl)-3-phenyl-propyl]-methyl-amine XX (Example 4). MS (M+H)=MS 311.

Sources & evidence

ORD record
ord-23a2307520284e7e878955b99eec1bbb
Source dataset
uspto-grants-2008_11
Patent number
US07446118B2

Reaction notes

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