反应详情

温度

150 °C

A mixture of ethyl 3-(4-chloro-phenyl)-3-oxo-propionate (5.8 g, 26.0 mmol) and 2H-pyrazol-3-ylamine (2.1 g, 26.0 mmol) was stirred at 150° C. for 2 h. EtOAc (22 mL) was successively added to the cooled mixture and stirring was continued at 0° C. for 0.5 h. The crystals were isolated by filtration to give 5-(4-chloro-phenyl)-pyrazolo[1,5-a]pyrimidine-7-ol (4.80 g, 75%) as a white solid. MS (ISP) 246.1 [(M+H)+]; mp 306-308° C.

1. stirringstirring
2. waitwas continued at 0° C. for 0.5 h
3. customThe crystals were isolated by filtration