反应详情

温度

120 °C

(R)-2-chloro-6-methyl-8-phenyl-5,6,7,8-tetrahydropyrimido[5,4-f][1,4]oxazepine (0.05 g, 0.18 mmol), 3-methoxy-4-(4-methyl-1H-imidazol-1-yl)aniline (0.037 g, 0.18 mmol) (0.65), PALLADIUM(II) ACETATE (1.221 mg, 5.44 µmol), CESIUM CARBONATE (0.071 g, 0.22 mmol) and Tri-tert- butylphosphonium tetrafluoriborate (0.0043 g, 0.014 mmol, 6 mol%) in 1 ml of dioxane was degaset over argone and heated in MW 120°C 30 min. 002 - 4.8% of conversion mixture was heated more in MW 140°C 30 min. 003 - 15% of conversion mixture was heated more in MW 160°C 30 min. Experiment was not progressed.