Hydrochloric Acid → 3-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid

HRID 26901Notes

Reaction equation

HRID 26901 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15](O)([CH3:20])[CH2:16][C:17]([OH:19])=[O:18])=[CH:11][CH:10]=1.Cl>C(O)(=O)C>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([C:15]([CH3:20])=[CH:16][C:17]([OH:19])=[O:18])=[CH:11][CH:10]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 213225833-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid

Product 1

HCID 540100683-(2',4'-Difluoro-4-biphenylyl)-2-butenoic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

1 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid is dissolved in 5 ml. of acetic acid. 1 ml. of concentrated hydrochloric acid is added and the mixture is allowed to stand for 2 hours at 20° and poured onto ice. After the customary work up, 3-(2',4'-difluoro-4-biphenylyl)-2-butenoic acid, m.p. 193-195°, is obtained.

Workup

  1. additionpoured onto ice

Sources & evidence

ORD record
ord-34cf583e09c244a5ad2473ff8ed3f4c8
Source dataset
uspto-grants-1979_04
Patent number
US04151302

Reaction notes

Loading…