Phosphoric Acid → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid ethyl ester

HRID 26905Notes

Reaction equation

HRID 26905 reaction equation
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][C:6]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[F:22])=[CH:11][CH:10]=1)(O)[CH3:7])[CH3:2].[I-].[K+].P(=O)(O)(O)O>>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][CH:6]([C:9]1[CH:14]=[CH:13][C:12]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][C:16]=2[F:22])=[CH:11][CH:10]=1)[CH3:7])[CH3:2]

Participants

4

Reactant 3

HCID 1004Phosphoric AcidHCID 4875Potassium IodideHCID 538342513-(2',4'-Difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester

Product 1

HCID 543401873-(2',4'-Difluoro-4-biphenylyl)butyric acid ethyl ester

Procedure

A mixture of 32 g. of 3-(2',4'-difluoro-4-biphenylyl)-3-hydroxybutyric acid ethyl ester, 8.7 g. of potassium iodide, 5.2 g. of red phosphorus and 45 ml. of 85% phosphoric acid is stirred and heated to 130° for 7 hours. It is worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid ethyl ester.

Workup

  1. additionA mixture of 32 g
  2. temperatureheated to 130° for 7 hours

Sources & evidence

ORD record
ord-085bc1f8311845d093222f9e2ed74cd1
Source dataset
uspto-grants-1979_04
Patent number
US04151302

Reaction notes

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