1-Propanol → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid n-propyl ester

HRID 26908Notes

Reaction equation

HRID 26908 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:20])[CH2:16][C:17](Cl)=[O:18])=[CH:11][CH:10]=1.[CH2:21]([OH:24])[CH2:22][CH3:23]>>[CH2:21]([O:24][C:17](=[O:18])[CH2:16][CH:15]([C:12]1[CH:11]=[CH:10][C:9]([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])=[CH:14][CH:13]=1)[CH3:20])[CH2:22][CH3:23]

Participants

3

Reactant 2

HCID 10311-PropanolHCID 213226013-(2',4'-Difluoro-4-biphenylyl)butyryl chloride

Product 1

HCID 541023453-(2',4'-Difluoro-4-biphenylyl)butyric acid n-propyl ester

Procedure

1 g. of crude 3-(2',4'-difluoro-4-biphenylyl)butyryl chloride and 10 ml. of n-propanol are warmed to 95° for 3 hours and the mixture is evaporated and worked up in the customary manner to give 3-(2',4'-difluoro-4-biphenylyl)butyric acid n-propyl ester.

Workup

  1. customthe mixture is evaporated

Sources & evidence

ORD record
ord-9302bc3901ba4e168b74ac392e9df468
Source dataset
uspto-grants-1979_04
Patent number
US04151302

Reaction notes

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