HCID 18936081, compound → HCID 18936072, compound

HRID 2692Notes

Reaction equation

HRID 2692 reaction equation
[P:1]([CH:5]([S:14]([OH:17])(=[O:16])=[O:15])[CH2:6][NH:7][C:8]1[CH:9]=[N:10][CH:11]=[CH:12][CH:13]=1)([OH:4])([OH:3])=[O:2]>[Pd].O>[P:1]([CH:5]([S:14]([OH:17])(=[O:15])=[O:16])[CH2:6][NH:7][CH:8]1[CH2:13][CH2:12][CH2:11][NH:10][CH2:9]1)([OH:4])([OH:3])=[O:2]

Participants

4

Reactant 1

HCID 18936081HCID 18936081, compound

Product 1

HCID 18936072HCID 18936072, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 962WaterSolvent

Procedure

A mixture of 1 g of 1-phosphono-2-(3-pyridinylamino)ethanesulfonic acid and 0.5 g of palladium on charcoal catalyst in 50 ml of distilled water is hydrogenated on a Parr apparatus at 40 PSI for about 2 days. The catalyst is removed by filtration, and the filtrate is concentrated to a few mls. Ethanol is added slowly to precipitate a solid, which is recrystallized from water/ethanol to afford 1-phosphono-2-(3-piperidinylamino)ethanesulfonic acid.

Workup

  1. customThe catalyst is removed by filtration
  2. concentrationthe filtrate is concentrated to a few mls
  3. additionEthanol is added slowly
  4. customto precipitate a solid, which
  5. customis recrystallized from water/ethanol

Sources & evidence

ORD record
ord-f8cd4bb1e8724101af770fd96846b25d
Source dataset
uspto-grants-1998_03
Patent number
US05731299

Reaction notes

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