5-Iodo-3-(trifluoromethyl)pyridin-2-amine → HCID 86608102, compound

HRID 269282Notes

Reaction equation

HRID 269282 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:17])([F:16])[F:15])[N:11]3[N:18]=[CH:19][C:20]([C:21]#[CH:22])=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.I[C:24]1[CH:25]=[C:26]([C:31]([F:34])([F:33])[F:32])[C:27]([NH2:30])=[N:28][CH:29]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[C:12]([C:14]([F:15])([F:17])[F:16])[N:11]3[N:18]=[CH:19][C:20]([C:21]#[C:22][C:24]4[CH:25]=[C:26]([C:31]([F:34])([F:33])[F:32])[C:27]([NH2:30])=[N:28][CH:29]=4)=[C:10]3[N:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 582353065-Iodo-3-(trifluoromethyl)pyridin-2-amineHCID 866079955-(4-Chloro-phenyl)-3-ethynyl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 86608102HCID 86608102, compound

Procedure

The title compound was prepared from 5-(4-chloro-phenyl)-3-ethynyl-7-trifluoromethyl-pyrazolo[1,5-a]pyrimidine (example C.4) (322 g, 1.0 mmol) and 5-iodo-3-trifluoromethyl-pyridin-2-ylamine (example B.48) (288 mg, 1.0 mmol) according to general procedure II. Obtained as an orange solid (290 mg, 60%). MS (ISP) 482.3 [(M+H)+], 484 [(M+2+H)+]; mp 209° C.

Sources & evidence

ORD record
ord-169c72ecbee04562a3ca4595ca69d064
Source dataset
uspto-grants-2008_11
Patent number
US07446113B2

Reaction notes

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