Acetic Acid → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid

HRID 26933Notes

Reaction equation

HRID 26933 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:20])[CH2:16][C:17](N)=[O:18])=[CH:11][CH:10]=1.Cl.C(O)(=[O:24])C>O>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][C:12]([CH:15]([CH3:20])[CH2:16][C:17]([OH:24])=[O:18])=[CH:11][CH:10]=1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 313Hydrochloric AcidHCID 21322520HCID 21322520, compound

Product 1

HCID 213225403-(2',4'-Difluoro-4-biphenylyl)butyric acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 1 g. of 3-(2',4'-difluoro-4-biphenylyl)butyramide, 2 ml. of concentrated hydrochloric acid and 2 ml. of acetic acid is heated under reflux for 48 hours and, after addition of water, is worked up in the customary manner to give 3-(2' ,4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.

Workup

  1. additionA mixture of 1 g
  2. temperatureunder reflux for 48 hours

Sources & evidence

ORD record
ord-dd3a03efb5834565871ebcb03de6856a
Source dataset
uspto-grants-1979_04
Patent number
US04151302

Reaction notes

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