Potassium Acetate → 3-Acetoxy-3-(2',4'-difluoro-4-biphenylyl)butan-1-ol

HRID 26935Notes

Reaction equation

HRID 26935 reaction equation
Br[C:2]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[F:20])=[CH:9][CH:8]=1)([CH3:6])[CH2:3][CH2:4][OH:5].FC1C=C(F)C=CC=1C1C=CC(C(C)CCO)=CC=1.[C:40]([O-:43])(=[O:42])[CH3:41].[K+]>>[C:40]([O:43][C:2]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[F:20])=[CH:9][CH:8]=1)([CH3:6])[CH2:3][CH2:4][OH:5])(=[O:42])[CH3:41]

Participants

4

Reactant 3

HCID 517044Potassium AcetateHCID 213225843-Bromo-3-(2',4'-difluoro-4-biphenylyl)butan-1-olHCID 213226043-(2',4'-Difluoro-4-biphenylyl)butan-1-ol

Product 1

HCID 213226263-Acetoxy-3-(2',4'-difluoro-4-biphenylyl)butan-1-ol

Procedure

Analogously to Example 25 (a), 3-bromo-3-(2',4'-difluoro-4-biphenylyl)butan-1-ol, obtained by brominating 3-(2',4'-difluoro-4-biphenylyl)butan-1-ol, and potassium acetate are reacted to give 3-acetoxy-3-(2',4'-difluoro-4-biphenylyl)butan-1-ol.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-3d33fbc7cbc74827a5ed2898b7fb5ec0
Source dataset
uspto-grants-1979_04
Patent number
US04151302

Reaction notes

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