5-Bromo-2-thiophenesulfonamide → HCID 67001042, compound

HRID 269358Notes

Reaction equation

HRID 269358 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][N:11]3[N:14]=[CH:15][C:16]([C:17]#[CH:18])=[C:10]3[N:9]=2)=[CH:4][CH:3]=1.Br[C:20]1[S:24][C:23]([S:25]([NH2:28])(=[O:27])=[O:26])=[CH:22][CH:21]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][N:11]3[N:14]=[CH:15][C:16]([C:17]#[C:18][C:20]4[S:24][C:23]([S:25]([NH2:28])(=[O:27])=[O:26])=[CH:22][CH:21]=4)=[C:10]3[N:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 12413045-Bromo-2-thiophenesulfonamideHCID 866080485-(4-Chloro-phenyl)-3-ethynyl-pyrazolo[1,5-a]pyrimidine

Product 1

HCID 67001042HCID 67001042, compound

Procedure

The title compound was prepared from 5-(4-chloro-phenyl)-3-ethynyl-pyrazolo[1,5-a]pyrimidine (example C.6) (37 mg, 0.17 mmol) and 5-bromo-thiophene-2-sulfonamide (35 mg, 0.17 mmol) according to general procedure II. Obtained as a yellow solid (45 mg, 74%). MS (ISP) 415.0 [(M+H)+].

Sources & evidence

ORD record
ord-4d4fd2c0b0544b02964053a1771299e7
Source dataset
uspto-grants-2008_11
Patent number
US07446113B2

Reaction notes

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