5-Bromo-2-thiophenesulfonamide → HCID 67000764, compound

HRID 269365Notes

Reaction equation

HRID 269365 reaction equation
[C:1]([C:3]1[CH:4]=[N:5][N:6]2[CH:11]=[CH:10][C:9]([C:12]3[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][CH:13]=3)=[N:8][C:7]=12)#[CH:2].Br[C:23]1[S:27][C:26]([S:28]([NH2:31])(=[O:30])=[O:29])=[CH:25][CH:24]=1>>[F:19][C:18]([F:20])([F:21])[C:15]1[CH:16]=[CH:17][C:12]([C:9]2[CH:10]=[CH:11][N:6]3[N:5]=[CH:4][C:3]([C:1]#[C:2][C:23]4[S:27][C:26]([S:28]([NH2:31])(=[O:30])=[O:29])=[CH:25][CH:24]=4)=[C:7]3[N:8]=2)=[CH:13][CH:14]=1

Participants

3

Reactant 2

HCID 12413045-Bromo-2-thiophenesulfonamideHCID 86608129HCID 86608129, compound

Product 1

HCID 67000764HCID 67000764, compound

Procedure

The title compound was prepared from 3-ethynyl-5-(4-trifluoromethyl-phenyl)-pyrazolo[1,5-a]pyrimidine (example C.33) (144 mg, 0.5 mmol) and 5-bromo-thiophene-2-sulfonic acid amide (121 mg, 0.5 mmol) according to general procedure II. Obtained as a yellow solid (153 mg, 68%). MS (ISP) 449.3 [(M+H)+]; mp 224-226° C.

Sources & evidence

ORD record
ord-ebc06c4e61644d2a853b8689136f86b9
Source dataset
uspto-grants-2008_11
Patent number
US07446113B2

Reaction notes

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