HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formaldehyde → 3-(2',4'-Difluoro-4-biphenylyl)butan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formaldehyde | HCID 712 | — |
| Reactant | Magnesium | HCID 5462224 | — |
| Reactant | 4'-(1-Bromopropan-2-yl)-2,4-difluoro-1,1'-biphenyl | HCID 53691440 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(2',4'-Difluoro-4-biphenylyl)butan-1-ol | HCID 21322604 | — |
Reaction Steps
0.3 g. of paraformaldehyde is added to Grignard solution prepared from 3.11 g. of 4-(1-bromo-2-propyl)-2',4'-difluorobiphenyl and 0.26 g. of magnesium powder in 40 ml. of THF and the mixture is allowed to stand for 5 days. It is worked up in the customary manner, using ice/dilute hydrochloric acid, to give 3-(2',4'-difluoro-4-biphenylyl)butan-1-ol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04151302 |
| Source dataset | uspto-grants-1979_04 |
| ORD ID | ord-069f9d7d9b204e55ae77b108521a7d88 |
| Source note | uspto-grants-1979_04 |