Formaldehyde → 3-(2',4'-Difluoro-4-biphenylyl)butan-1-ol

HRID 26938Notes

Reaction equation

HRID 26938 reaction equation
[CH2:1]=[O:2].Br[CH2:4][CH:5]([C:7]1[CH:12]=[CH:11][C:10]([C:13]2[CH:18]=[CH:17][C:16]([F:19])=[CH:15][C:14]=2[F:20])=[CH:9][CH:8]=1)[CH3:6].[Mg]>C1COCC1>[F:20][C:14]1[CH:15]=[C:16]([F:19])[CH:17]=[CH:18][C:13]=1[C:10]1[CH:11]=[CH:12][C:7]([CH:5]([CH3:6])[CH2:4][CH2:1][OH:2])=[CH:8][CH:9]=1

Participants

5

Reactant 3

HCID 712FormaldehydeHCID 5462224MagnesiumHCID 536914404'-(1-Bromopropan-2-yl)-2,4-difluoro-1,1'-biphenyl

Product 1

HCID 213226043-(2',4'-Difluoro-4-biphenylyl)butan-1-ol

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

0.3 g. of paraformaldehyde is added to Grignard solution prepared from 3.11 g. of 4-(1-bromo-2-propyl)-2',4'-difluorobiphenyl and 0.26 g. of magnesium powder in 40 ml. of THF and the mixture is allowed to stand for 5 days. It is worked up in the customary manner, using ice/dilute hydrochloric acid, to give 3-(2',4'-difluoro-4-biphenylyl)butan-1-ol.

Workup

  1. customprepared from 3.11 g

Sources & evidence

ORD record
ord-069f9d7d9b204e55ae77b108521a7d88
Source dataset
uspto-grants-1979_04
Patent number
US04151302

Reaction notes

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