HRID269382

反应详情

EQUATION

反应方程式

HRID 269382 的结构方程式

AUXILIARIES

试剂、催化剂与溶剂

2

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

The mixture of 5,6-dimethoxy-2-(4-pyridyl)methylene-1-indanone (34 gm), methanol (325 ml), methylenedichloride (200 ml) and 5% palladium-charcoal (2 gm) is taken in a hydrogenation flask and subjected to hydrogenation under a hydrogen pressure of 2 bars for 3 hours. The catalyst is removed by filtration and the solvents are evaporated completely under vacuum to obtain a residue. Ethyl acetate (150 ml) is added to the residue and stirred for 20 minutes at 25° C. to 30° C. The contents are then cooled to 0° C., stirred for 30 minutes and filtered to give 34 gm of 5,6-dimethoxy-2-(4-pyridyl)methyl-1-indanone.

WORKUP

后处理

  1. customis taken in a hydrogenation flask
  2. customfor 3 hours
  3. customThe catalyst is removed by filtration
  4. customthe solvents are evaporated completely under vacuum
  5. customto obtain a residue
  6. stirringstirred for 30 minutes
  7. filtrationfiltered