Carbon Dioxide → 3-(2',4'-Difluoro-4-biphenylyl)butyric acid

HRID 26942Notes

Reaction equation

HRID 26942 reaction equation
C([O:3][C:4](=[O:27])[CH:5]([CH:11]([C:13]1[CH:18]=[CH:17][C:16]([C:19]2[CH:24]=[CH:23][C:22]([F:25])=[CH:21][C:20]=2[F:26])=[CH:15][CH:14]=1)[CH3:12])C(OCC)=O)C.[OH-].[K+].Cl.C(=O)=O>C(O)(=O)C>[F:26][C:20]1[CH:21]=[C:22]([F:25])[CH:23]=[CH:24][C:19]=1[C:16]1[CH:17]=[CH:18][C:13]([CH:11]([CH3:12])[CH2:5][C:4]([OH:27])=[O:3])=[CH:14][CH:15]=1

Participants

6

Reactant 4

HCID 280Carbon DioxideHCID 313Hydrochloric AcidHCID 14797Potassium HydroxideHCID 54297923HCID 54297923, compound

Product 1

HCID 213225403-(2',4'-Difluoro-4-biphenylyl)butyric acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of crude 1-(2',4'-difluoro-4-biphenylyl)ethylmalonic acid, obtained by saponifying 2 g. of 1-(2',4'-difluoro-4-biphenylyl)ethylmalonic acid diethyl ester with ethanolic KOH under N2, in 20 ml. of acetic acid and 20 ml. of 15% HCl is heated under reflux under N2 until evolution of CO2 has ceased. After cooling, the customary work up gives 3-(2',4'-difluoro-4-biphenylyl)butyric acid, m.p. 109°-110°.

Workup

  1. temperatureAfter cooling

Sources & evidence

ORD record
ord-6277d8edc02b44fe9084b198119d6752
Source dataset
uspto-grants-1979_04
Patent number
US04151302

Reaction notes

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