反应详情

A solution of 2-(5-chloropentyloxy)tetrahydro-2H-pyrane (10) (20.67 g, 0.1 mol) in dry acetone (50 mL) was added in drops to a magnetically stirred solution of sodium iodide (16.49 g, 0.11 mol) in dry acetone (150 mL). The reaction mixture was refluxed in a nitrogen atmosphere over night. After cooling the precipitated sodium chloride was filtered out and acetone was distilled out on a rotary evaporator. The residue which still contained some sodium chloride was dissolved in dry pentane (200 mL). Sodium chloride was filtered out and pentane distilled out on a rotary evaporator, yielding 26.2 g (88%) of a yellowish brown oil. NMR indicated a pure product.

1. temperatureThe reaction mixture was refluxed in a nitrogen atmosphere over night
2. filtrationwas filtered out and acetone
3. distillationwas distilled out on a rotary evaporator
4. dissolutionwas dissolved in dry pentane (200 mL)
5. filtrationSodium chloride was filtered out and pentane
6. distillationdistilled out on a rotary evaporator