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To a solution of 99.1 g (0.49 mol) of diethyl isopropylmalonate in 500 ml of THF, 11.7 g (0.49 mol) of sodium hydride was added. This mixture was refluxed for 1 h and then cooled to room temperature. Next, 120 g (0.49 mol) of 2-bromobenzylbromide was added, and the resulting mixture was refluxed for 3 h. This mixture was cooled to ambient temperature and filtered through a glass frit (G2). The precipitate (NaBr) was additionally washed with 3×100 ml of THF. The combined filtrate was evaporated to dryness. The residue was dissolved in 400 ml of ethanol and 160 g of potassium hydroxide and 50 ml of water were added. The resulting mixture was refluxed for 4 h, and then 200 ml of water was added. Ethanol was distilled off at atmospheric pressure. The resulting aqueous solution was acidified with 5 M HCl to pH 1. The precipitate obtained at −30° C. was filtered off, washed with 100 ml of water, and dried in air. The dibasic acid was decarboxylated by heating for 2 h at 160° C. The product obtained was dissolved in 600 ml of dichloromethane, and 600 ml of SOCl2 was added. The mixture was refluxed for 3 h and then evaporated to dryness. The residue was dissolved in 270 ml of dry dichloromethane, and the solution obtained was added dropwise to a suspension of 136 g (1.02 mol) of AlCl3 in 1350 ml of dichloromethane for 1 h at 0° C., while vigorously stirring. Next, the reaction mixture was refluxed for 3 h, cooled to ambient temperature, poured on 500 cm3 of ice, and, finally, acidified with 8M HCl to pH 3. The organic layer was separated, the aqueous layer was washed with 3×300 ml of methyl-tert-butyl ether. The combined organic fractions were dried over K2CO3 and then evaporated to dryness. The product was isolated by vacuum distillation (bp 154-157° C./3 mm Hg). Yield 73.4 g (60%).

1. temperatureThis mixture was refluxed for 1 h
2. temperaturethe resulting mixture was refluxed for 3 h
3. temperatureThis mixture was cooled to ambient temperature
4. filtrationfiltered through a glass frit (G2)
5. washThe precipitate (NaBr) was additionally washed with 3×100 ml of THF
6. customThe combined filtrate was evaporated to dryness
7. dissolutionThe residue was dissolved in 400 ml of ethanol
8. addition160 g of potassium hydroxide and 50 ml of water were added
9. temperatureThe resulting mixture was refluxed for 4 h
10. addition200 ml of water was added
11. distillationEthanol was distilled off at atmospheric pressure
12. customThe precipitate obtained at −30° C.
13. filtrationwas filtered off
14. washwashed with 100 ml of water
15. customdried in air
16. temperatureby heating for 2 h at 160° C
17. customThe product obtained
18. temperatureThe mixture was refluxed for 3 h
19. customevaporated to dryness
20. dissolutionThe residue was dissolved in 270 ml of dry dichloromethane
21. customthe solution obtained
22. temperatureNext, the reaction mixture was refluxed for 3 h
23. temperaturecooled to ambient temperature
24. customThe organic layer was separated
25. washthe aqueous layer was washed with 3×300 ml of methyl-tert-butyl ether
26. dry with materialThe combined organic fractions were dried over K2CO3
27. customevaporated to dryness
28. customThe product was isolated by vacuum distillation (bp 154-157° C./3 mm Hg)