Lawesson's reagent → HCID 59832201, compound

HRID 269499Notes

Reaction equation

HRID 269499 reaction equation
[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[NH:9][C:10]([C:12]1[C:20]2[C:15](=[N:16][CH:17]=[C:18]([Br:21])[CH:19]=2)[NH:14][CH:13]=1)=O.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:31])=CC=1>C1(C)C=CC=CC=1>[F:1][C:2]1[C:7]([F:8])=[CH:6][CH:5]=[CH:4][C:3]=1[NH:9][C:10]([C:12]1[C:20]2[C:15](=[N:16][CH:17]=[C:18]([Br:21])[CH:19]=2)[NH:14][CH:13]=1)=[S:31]

Participants

4

Reactant 2

HCID 87949Lawesson's reagentHCID 598322925-Bromo-N-(2,3-difluorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamide

Product 1

HCID 59832201HCID 59832201, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

To a solution of 5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid (2,3-difluoro-phenyl)-amide (300 mg, 0.85 mmol) in toluene (6 mL) was added Lawesson's reagent (210 mg, 0.52 mmol). The suspension was heated under reflux for 14 h. The solvent was removed by evaporation and the residue was dried on the pump for the next reaction. MS (ES+): m/e=368 (M+H); LC: 3.6 min.

Workup

  1. temperatureThe suspension was heated
  2. temperatureunder reflux for 14 h
  3. customThe solvent was removed by evaporation
  4. customthe residue was dried on the pump for the next reaction
  5. custom3.6 min.

Sources & evidence

ORD record
ord-3985e1ea33ed46d28cbada817a6d8aa5
Source dataset
uspto-grants-2008_11
Patent number
US07446199B2

Reaction notes

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