反应详情

温度

90 °C

A mixture of 3-acetylphenylboronic acid (1.64 g, 10 mmol), 1,2-dibromobenzene (4.72 g, 20 mmol), potassium carbonate (6.9 g, 50 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.58 g, 0.5 mmol) in 1:1 toluene/ethanol (40 ml) was stirred and heated at 90° C. under nitrogen for 16 hours. After cooling the mixture was diluted with diethyl ether and water and the organic phase dried (MgSO4) and evaporated to dryness. The residue was purified by chromatography using Biotage with iso-hexane containing a gradient of dichloromethane (20-50%) to yield the title compound as a white solid (1.74 g 63%).

1. temperatureAfter cooling the mixture
2. dry with materialthe organic phase dried (MgSO4)
3. customevaporated to dryness
4. customThe residue was purified by chromatography