反应详情

温度

90 °C

A mixture of 2′-benzyloxy-biphenyl-2-boronic acid (61 mg, 0.2 mmol), ethyl 2-bromo-5-chlorobenzoate (53 mg, 0.2 mmol), potassium carbonate (207 mg, 1.5 mmol) and tetrakis(triphenylphosphine)palladium(0) (23 mg, 0.02 mmol) in 1:1 toluene/ethanol (3 ml) was stirred and heated at 90° C. under nitrogen for 2 hours. After cooling the mixture was diluted with diethyl ether and water and the organic phase dried (MgSO4) and evaporated to dryness. The residue was purified using Biotage with ethyl acetate/iso-hexane (1:19) to yield the title compound as a colourless gum (63 mg, 71%).

1. temperatureAfter cooling the mixture
2. dry with materialthe organic phase dried (MgSO4)
3. customevaporated to dryness
4. customThe residue was purified