関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Methyl 5-amino-2-bromobenzoate | HCID 245495 | — |
| 反応物 | (2-Bromophenyl)boronic acid | HCID 2773294 | — |
| 反応物 | Toluene ethanol | HCID 21863594 | — |
| 触媒 | HCID 178418397 | HCID 178418397 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | Diethyl Ether | HCID 3283 | — |
| 生成物 | Methyl 4-amino-2'-bromo-2-biphenylcarboxylate | HCID 58730987 | — |
反応手順
A mixture of 2-bromophenyl boronic acid (600 mg, 3.0 mmol), methyl 5-amino-2-bromobenzoate (1.5 g, 6.5 mmol), potassium carbonate (2.07 g, 15 mmol) and tetrakis(triphenylphosphine)palladium (0) (345 mg, 5 mol %) in 1:1 toluene/ethanol (20 ml) was stirred and heated at 90° C. under nitrogen for 12 hours. After cooling the mixture was diluted with diethyl ether and water and the organic phase dried (MgSO4) and evaporated to dryness. The residue was chromatographed with dichloromethane/iso-hexane (1:2->1:1) to yield the title compound as a pale yellow gum. (682 mg, 74%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07446222B2 |
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| 出典データセット | uspto-grants-2008_11 |
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| ORD ID | ord-273f753770b94019aec781ec869b4b74 |
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| 出典メモ | uspto-grants-2008_11 |
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