反应详情

A mixture of ethyl 6-(5′-chloro-2′-hydroxy-2-biphenylyl)-2-pyridinecarboxylate (177 mg, 0.5 mmol), potassium carbonate (138 mg, 1 mmol) and 4-fluorobenzyl bromide (104 mg, 0.55 mmol) in acetone (4 ml) was stirred and refluxed for 2 hours then cooled, filtered, evaporated and chromatographed on silica eluting with ethyl acetate/iso-hexane (1:9) to give 190 mg of white solid. LC/MS t=3.79, [MH+] 462.3

1. temperaturerefluxed for 2 hours
2. temperaturethen cooled
3. filtrationfiltered
4. customevaporated
5. customchromatographed on silica eluting with ethyl acetate/iso-hexane (1:9)