2'-Bromo-2-{[(4-fluorophenyl)methyl]oxy}-5-(trifluoromethyl)biphenyl → [2'-{[(4-Fluorophenyl)methyl]oxy}-5'-(trifluoromethyl)-2-biphenylyl]boronic acid

HRID 269574Notes

Reaction equation

HRID 269574 reaction equation
ClC1C=CC(OCC2C=CC=CC=2)=C(C2C=CC=CC=2[B:14]([OH:16])[OH:15])C=1.Br[C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=1[C:32]1[CH:37]=[C:36]([C:38]([F:41])([F:40])[F:39])[CH:35]=[CH:34][C:33]=1[O:42][CH2:43][C:44]1[CH:49]=[CH:48][C:47]([F:50])=[CH:46][CH:45]=1>>[F:50][C:47]1[CH:48]=[CH:49][C:44]([CH2:43][O:42][C:33]2[CH:34]=[CH:35][C:36]([C:38]([F:41])([F:40])[F:39])=[CH:37][C:32]=2[C:27]2[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=2[B:14]([OH:16])[OH:15])=[CH:45][CH:46]=1

Participants

3

Reactant 2

HCID 693109592'-Bromo-2-{[(4-fluorophenyl)methyl]oxy}-5-(trifluoromethyl)biphenylHCID 69312320{5'-Chloro-2'-[(phenylmethyl)oxy]-2-biphenylyl}boronic acid

Product 1

HCID 69310930[2'-{[(4-Fluorophenyl)methyl]oxy}-5'-(trifluoromethyl)-2-biphenylyl]boronic acid

Procedure

Prepared as for {5′-chloro-2′-[(phenylmethyl)oxy]-2-biphenylyl}boronic acid but using 2′-bromo-2-{[(4-fluorophenyl)methyl]oxy}-5-(trifluoromethyl)biphenyl instead of 2′-bromo-5-chloro-2-[(phenylmethyl)oxy]biphenyl. LC/MS t=3.63, [MH−] 389.0

Sources & evidence

ORD record
ord-b6d0186af34748df905e55d9c70488cb
Source dataset
uspto-grants-2008_11
Patent number
US07446222B2

Reaction notes

Loading…