反应详情

5-Chloro-2-pyridinol (5.18 g, 40 mmol) was dissolved in glacial acetic acid (50 ml) and bromine (7.51 g, 2.41 ml, 47 mmol) added. The mixture was stirred at room temperature for 48 hours. Ethyl acetate and water were added and the organic layer washed with water (×3), dried (MgSO4) and evaporated. The residue was triturated with diethyl ether and the buff solid filtered and dried (5.59 g).

1. washthe organic layer washed with water (×3)
2. dry with materialdried (MgSO4)
3. customevaporated
4. customThe residue was triturated with diethyl ether
5. filtrationthe buff solid filtered
6. customdried (5.59 g)