反应详情

3-Bromo-5-chloro-2-pyridinol (7.0 g, 33.6 mmol) was stirred in toluene (160 ml) and silver carbonate (10.23 g, 36.9 mmol) added, followed by benzyl bromide (6.32 g, 4.39 ml, 36.9 mmol). The mixture was heated to reflux for 1 hour. After cooling, the mixture was filtered, washed with water (×2), dried (MgSO4) and evaporated. The residue was triturated with isohexane and the pale yellow solid filtered and dried. (8.36 g).

1. temperatureThe mixture was heated
2. temperatureto reflux for 1 hour
3. temperatureAfter cooling
4. filtrationthe mixture was filtered
5. washwashed with water (×2)
6. dry with materialdried (MgSO4)
7. customevaporated
8. customThe residue was triturated with isohexane
9. filtrationthe pale yellow solid filtered
10. customdried