反应详情

41 g (101.7 mmol) of 1-benzyloxy-2-bromomethyl-4-iodobenzene (Example 4A) are added to a solution of 28 g (101.7 mmol) of diethyl 2-[N-(tert-butoxycarbonyl)amino]malonate and 7.9 ml (101.7 mmol) of sodium ethoxide in 300 ml of ethanol. After stirring at RT for 3 h, the precipitated product is collected by suction filtration. After drying in vacuo, 55 g (90% of theory) of product are isolated.

1. filtrationthe precipitated product is collected by suction filtration
2. customAfter drying in vacuo, 55 g (90% of theory) of product
3. customare isolated