反应详情

温度

70 °C

A solution of 218 mg (0.55 mmol) of (2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl methanesulfonate (Example 84A) in 15 ml of dimethylformamide is mixed with 36 mg (0.55 mmol) of sodium azide and stirred at 70° C. for 12 h. Most of the solvent is removed by distillation in vacuo, and the residue is diluted with ethyl acetate. The mixture is washed several times with a saturated sodium bicarbonate solution, dried over magnesium sulfate and evaporated to dryness in vacuo. The product is reacted without further purification.

1. customMost of the solvent is removed by distillation in vacuo
2. additionthe residue is diluted with ethyl acetate
3. washThe mixture is washed several times with a saturated sodium bicarbonate solution
4. dry with materialdried over magnesium sulfate
5. customevaporated to dryness in vacuo
6. customThe product is reacted without further purification