Hydrochloric Acid → HCID 69215943, compound

HRID 269623Notes

Reaction equation

HRID 269623 reaction equation
C([O:8][C:9](=[O:47])[NH:10][CH2:11][CH2:12][NH:13][C:14](=[O:46])[C@@H:15]([NH:38]C(OC(C)(C)C)=O)[CH2:16][C@@H:17]([O:30][Si:31]([C:34]([CH3:37])([CH3:36])[CH3:35])([CH3:33])[CH3:32])[CH2:18][NH:19][C:20]([O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:21])C1C=CC=CC=1.[ClH:48]>O1CCOCC1>[ClH:48].[CH2:23]([N:10]([CH2:11][CH2:12][NH:13][C:14](=[O:46])[C@@H:15]([NH2:38])[CH2:16][C@@H:17]([O:30][Si:31]([C:34]([CH3:37])([CH3:36])[CH3:35])([CH3:32])[CH3:33])[CH2:18][NH:19][C:20]([O:22][CH2:23][C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[O:21])[C:9](=[O:47])[OH:8])[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131727149HCID 131727149, compound

Product 1

HCID 69215943HCID 69215943, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

53 mg (0.08 mmol) of the compound from Example 95A are cooled to 0° C., and 1 ml of 4N hydrogen chloride in dioxane is added. After 1 h, concentration in vacuo results in the title compound.

Workup

  1. concentrationconcentration in vacuo

Sources & evidence

ORD record
ord-9c2f459f662b433bb2d57139d582ec06
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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