HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 269624Generated: November 3, 2026
1,2-Dichloroethane → benzyl{(1S)-3-[(tert-butoxycarbonyl)amino]-1-[({3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}amino)carbonyl]propyl}carbamate
https://huagongshe.com/reaction/269624
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1,2-Dichloroethane | HCID 11 | — |
| Reactant | 1-Hydroxybenzotriazole | HCID 75771 | — |
| Reactant | (S)-2-(((Benzyloxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid | HCID 7019789 | — |
| Reactant | tert-butyl N-(3-amino-2-hydroxypropyl)carbamate | HCID 10511887 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | benzyl{(1S)-3-[(tert-butoxycarbonyl)amino]-1-[({3-[(tert-butoxycarbonyl)amino]-2-hydroxypropyl}amino)carbonyl]propyl}carbamate | HCID 131727150 | — |
Reaction Steps
44 mg (0.12 mmol) of the compound from Example 97A and 40 mg (0.21 mmol) of tert-butyl(3-amino-2-hydroxypropyl)carbamate are dissolved in 1 ml of DMF and cooled to 0° C., and 40.3 mg (0.21 mmol) of EDC and 5.51 mg (0.04 mmol) of HOBt are successively added. The mixture is allowed to warm to room temperature and is stirred overnight. After concentration in vacuo, purification by chromatography on silica gel (dichloromethane/methanol 20:1) results in the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07446102B2 |
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| Source dataset | uspto-grants-2008_11 |
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| ORD ID | ord-7e20b9c9056f40c2be3c2d09c4273fed |
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| Source note | uspto-grants-2008_11 |
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