huagongshe.com
HRID269624

反应详情

EQUATION

反应方程式

HRID 269624 的结构方程式

REACTANTS

反应物

4
结构：ClCCCl
HCID11

1,2-Dichloroethane

C2H4Cl2

结构：On1nnc2ccccc21
HCID75771

1-Hydroxybenzotriazole

C6H5N3O

结构：CC(C)(C)OC(=O)NCC[C@H](NC(=O)OCc1ccccc1)C(=O)O
HCID7019789

(S)-2-(((Benzyloxy)carbonyl)amino)-4-((tert-butoxycarbonyl)amino)butanoic acid

C17H24N2O6

结构：CC(C)(C)OC(=O)NCC(O)CN
HCID10511887

tert-Butyl (3-amino-2-hydroxypropyl)carbamate

C8H18N2O3

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NCC[C@H](NC(=O)OCc1ccccc1)C(=O)NCC(O)CNC(=O)OC(C)(C)C
HCID131727150

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

44 mg (0.12 mmol) of the compound from Example 97A and 40 mg (0.21 mmol) of tert-butyl(3-amino-2-hydroxypropyl)carbamate are dissolved in 1 ml of DMF and cooled to 0° C., and 40.3 mg (0.21 mmol) of EDC and 5.51 mg (0.04 mmol) of HOBt are successively added. The mixture is allowed to warm to room temperature and is stirred overnight. After concentration in vacuo, purification by chromatography on silica gel (dichloromethane/methanol 20:1) results in the title compound.

WORKUP

后处理

  1. temperatureto warm to room temperature
  2. concentrationAfter concentration
  3. customin vacuo, purification by chromatography on silica gel (dichloromethane/methanol 20:1)