Hydrochloric Acid → HCID 69216959, compound

HRID 269633Notes

Reaction equation

HRID 269633 reaction equation
[ClH:1].[CH2:2]([O:9][C:10](=[O:59])[NH:11][CH2:12][CH2:13][NH:14][C:15](=[O:58])[CH2:16][C@@H:17]([NH:47][C:48]([O:50][CH2:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1)=[O:49])[CH2:18][CH2:19][CH2:20][NH:21][C:22](=[O:46])[C@H:23]([CH2:32][CH2:33][CH2:34][NH:35][C:36]([O:38]CC1C=CC=CC=1)=[O:37])[NH:24]C(OC(C)(C)C)=O)[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCOCC1>[ClH:1].[CH2:2]([N:35]([CH2:34][CH2:33][CH2:32][C@H:23]([NH2:24])[C:22](=[O:46])[NH:21][CH2:20][CH2:19][CH2:18][C@H:17]([NH:47][C:48]([O:50][CH2:51][C:52]1[CH:57]=[CH:56][CH:55]=[CH:54][CH:53]=1)=[O:49])[CH2:16][C:15](=[O:58])[NH:14][CH2:13][CH2:12][NH:11][C:10](=[O:59])[O:9][CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[C:36](=[O:37])[OH:38])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86624503Benzyl {2-[((3S)-3-{[(benzyloxy)carbonyl]amino}-6-{[N5-[(benzyloxy)carbonyl]-N2-(tert-butoxycarbonyl)-L-ornithyl]amino}hexanoyl)amino]ethyl}carbamate

Product 1

HCID 69216959HCID 69216959, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

2.5 ml of a 4M solution of hydrogen chloride in dioxane are added to a solution of 48 mg (0.060 mmol) of benzyl{2-[((3S)-3-{[(benzyloxy)carbonyl]amino}-6-{[N5-[(benzyloxy)carbonyl]-N2-(tert-butoxycarbonyl)-L-ornithyl]amino}hexanoyl)amino]ethyl}carbamate (Example 106A) in 1 ml of dioxane at RT. After 4 h at RT, the reaction solution is concentrated in vacuo, coevaporated with dichloromethane several times and dried under high vacuum. The crude product is reacted without further purification.

Workup

  1. concentrationthe reaction solution is concentrated in vacuo
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

Sources & evidence

ORD record
ord-573c722c852946eab2101eaa90bcdd2b
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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