反应详情

A mixture of 400 mg (0.73 mmol) of benzyl[2-({(2S)-5-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]pentanoyl}amino)ethyl]carbamate (Example 121A) and 1 ml of a 4M solution of hydrogen chloride in dioxane is stirred at RT for 2 h. The reaction solution is concentrated, coevaporated with dichloromethane several times and dried under high vacuum. The crude product is reacted without further purification.

1. concentrationThe reaction solution is concentrated
2. customdried under high vacuum
3. customThe crude product is reacted without further purification