Hydrochloric Acid → HCID 69218499, compound

HRID 269643Notes

Reaction equation

HRID 269643 reaction equation
[CH2:1]([O:8][C:9](=[O:39])[NH:10][CH2:11][CH2:12][NH:13][C:14](=[O:38])[C@@H:15]([NH:30]C(OC(C)(C)C)=O)[CH2:16][CH2:17][CH2:18][NH:19][C:20]([O:22]CC1C=CC=CC=1)=[O:21])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:40]>O1CCOCC1>[ClH:40].[CH2:1]([N:19]([CH2:18][CH2:17][CH2:16][C@H:15]([NH2:30])[C:14]([NH:13][CH2:12][CH2:11][NH:10][C:9]([O:8][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)=[O:39])=[O:38])[C:20](=[O:21])[OH:22])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131727156Benzyl[2-({(2s)-5-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]pentanoyl}amino)ethyl]carbamate

Product 1

HCID 69218499HCID 69218499, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A mixture of 400 mg (0.73 mmol) of benzyl[2-({(2S)-5-{[(benzyloxy)carbonyl]amino}-2-[(tert-butoxycarbonyl)amino]pentanoyl}amino)ethyl]carbamate (Example 121A) and 1 ml of a 4M solution of hydrogen chloride in dioxane is stirred at RT for 2 h. The reaction solution is concentrated, coevaporated with dichloromethane several times and dried under high vacuum. The crude product is reacted without further purification.

Workup

  1. concentrationThe reaction solution is concentrated
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

Sources & evidence

ORD record
ord-d8d5957a7ce441169191d5400b800ac5
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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