HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzyl [2-({(2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl}amino)-2-oxoethyl]carbamate → tert-Butyl {(4S)-5-[(aminoacetyl)amino]-4-[(tert-butoxycarbonyl)amino]pentyl}carbamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzyl [2-({(2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl}amino)-2-oxoethyl]carbamate | HCID 86624495 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | tert-Butyl {(4S)-5-[(aminoacetyl)amino]-4-[(tert-butoxycarbonyl)amino]pentyl}carbamate | HCID 86624496 | — |
Reaction Steps
Preparation takes place in analogy to Example 81A from 105 mg (0.21 mmol) of benzyl[2-({(2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl}amino)-2-oxoethyl]carbamate (Example 125A) in 50 ml of ethanol with the addition of 11 mg of palladium on activated carbon (10%). The product is reacted without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07446102B2 |
| Source dataset | uspto-grants-2008_11 |
| ORD ID | ord-0d68d4ddee95466e87978181337225a4 |
| Source note | uspto-grants-2008_11 |