Piperidine → tert-butyl[(1S)-4-[(tert-butoxycarbonyl)amino]-1-({[(2s)-2,5-diamino-5-oxopentanoyl]amino}methyl)butyl]carbamate

Participants

Reaction Steps

A solution of 33 mg (0.05 mmol) of 9H-fluoren-9-ylmethyl{(1S)-4-amino-1-[({(2S)-2,5-bis[(tert-butoxycarbonyl)amino]pentyl}amino)carbonyl]-4-oxobutyl}carbamate (Example 129A) in 1 ml of dimethylformamide is stirred after the addition of 4 mg (0.05 mmol) of piperidine at room temperature for 45 min. The solvent is evaporated and the crude product is reacted without further purification.

Provenance & Evidence