Hydrochloric Acid → HCID 86619435, compound

HRID 269658Notes

Reaction equation

HRID 269658 reaction equation
[ClH:1].[CH2:2]([O:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][C@@H:16]([C:25]([NH:27][C@H:28]([C:31]([NH:33][CH2:34][CH2:35][NH:36][C:37]([O:39][CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)=[O:38])=[O:32])[CH2:29][OH:30])=[O:26])[NH:17]C(OC(C)(C)C)=O)=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1>O1CCOCC1>[ClH:1].[CH2:2]([O:9][C:10]([NH:12][CH2:13][CH2:14][CH2:15][C@@H:16]([C:25]([NH:27][C@H:28]([C:31]([NH:33][CH2:34][CH2:35][NH:36][C:37]([O:39][CH2:40][C:41]1[CH:46]=[CH:45][CH:44]=[CH:43][CH:42]=1)=[O:38])=[O:32])[CH2:29][OH:30])=[O:26])[NH2:17])=[O:11])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86619437HCID 86619437, compound

Product 1

HCID 86619435HCID 86619435, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

10 ml of a 4M solution of hydrogen chloride in dioxane are added to a solution of 120 mg (0.191 mmol) of N5-[(benzyloxy)carbonyl]-N2-(tert-butoxycarbonyl)-L-ornithyl-N-(2-{[(benzyloxy)carbonyl]amino}ethyl)-L-serinamide (Example 164A) in 5 ml of dioxane at RT. The mixture is stirred at RT for 1 h. The reaction solution is concentrated, coevaporated with dichloromethane several times and dried under high vacuum. The crude product is reacted without further purification.

Workup

  1. concentrationThe reaction solution is concentrated
  2. customdried under high vacuum
  3. customThe crude product is reacted without further purification

Sources & evidence

ORD record
ord-803292fd5bc245fcbbba1149e608a247
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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