HCID 69219291, compound → HCID 86619438, compound

HRID 269665Notes

Reaction equation

HRID 269665 reaction equation
C(OC([NH:11][C@@H:12]([C:24]([NH:26][CH2:27][CH2:28][CH2:29][C@@H:30]([C:39]([NH:41][CH2:42][CH2:43][NH:44][C:45]([O:47][C:48]([CH3:51])([CH3:50])[CH3:49])=[O:46])=[O:40])[NH:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])=[O:25])[CH2:13][CH2:14][CH2:15][NH:16][C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])=O)C1C=CC=CC=1>C(O)C.[Pd]>[C:20]([O:19][C:17]([NH:16][CH2:15][CH2:14][CH2:13][C@H:12]([C:24]([NH:26][CH2:27][CH2:28][CH2:29][C@@H:30]([C:39]([NH:41][CH2:42][CH2:43][NH:44][C:45]([O:47][C:48]([CH3:51])([CH3:50])[CH3:49])=[O:46])=[O:40])[NH:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])=[O:25])[NH2:11])=[O:18])([CH3:21])([CH3:22])[CH3:23]

Participants

4

Reactant 1

HCID 69219291HCID 69219291, compound

Product 1

HCID 86619438HCID 86619438, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

0.58 g (0.80 mmol) of the compound from Example 228A are dissolved in 27 ml of ethanol, and 0.06 g (0.06 mmol) of Pd/C are added. The mixture is hydrogenated under atmospheric pressure for 12 h and, after filtration through celite, the filtrate is concentrated in vacuo. The solid obtained in this way is reacted further without purification.

Workup

  1. filtrationafter filtration through celite
  2. concentrationthe filtrate is concentrated in vacuo
  3. customThe solid obtained in this way
  4. customis reacted further without purification

Sources & evidence

ORD record
ord-3571a78ceb234f899d5335e89a6ca33c
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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