HCID 86619454, compound → HCID 86619453, compound

HRID 269691Notes

Reaction equation

HRID 269691 reaction equation
C(OC([NH:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][CH2:18][C@@H:19]([C:28]([NH:30][CH2:31][CH2:32][NH:33][C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])=[O:29])[NH:20][C:21]([O:23][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:22])=[O:14])=O)C1C=CC=CC=1>C(O)C.[Pd]>[NH2:11][CH2:12][C:13]([NH:15][CH2:16][CH2:17][CH2:18][C@@H:19]([C:28]([NH:30][CH2:31][CH2:32][NH:33][C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])=[O:29])[NH:20][C:21]([O:23][C:24]([CH3:26])([CH3:27])[CH3:25])=[O:22])=[O:14]

Participants

4

Reactant 1

HCID 86619454HCID 86619454, compound

Product 1

HCID 86619453HCID 86619453, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

1030 mg (1.82 mmol) of the compound from Example 263A are dissolved in 60 ml of ethanol, and 100 mg (0.09 mmol) of Pd/C (10%) are added. The mixture is hydrogenated under atmospheric pressure overnight and, after filtration through celite, the filtrate is concentrated in vacuo. The solid obtained in this way is reacted further without purification.

Workup

  1. customis hydrogenated under atmospheric pressure overnight
  2. filtrationafter filtration through celite
  3. concentrationthe filtrate is concentrated in vacuo
  4. customThe solid obtained in this way
  5. customis reacted further without purification

Sources & evidence

ORD record
ord-22b3a6f4b61d43f499ea052ada674ad6
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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