HCID 131727172, compound → HCID 86619455, compound

HRID 269692Notes

Reaction equation

HRID 269692 reaction equation
C(OC(=O)[NH:10][C@@H:11]([CH2:40][CH2:41][NH:42][C:43]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])=[O:44])[C:12](=[O:39])[NH:13][CH2:14][CH2:15][CH2:16][C@H:17]([NH:31][C:32]([O:34][C:35]([CH3:38])([CH3:37])[CH3:36])=[O:33])[C:18](=[O:30])[NH:19][CH2:20][CH2:21][NH:22][C:23](=[O:29])[O:24][C:25]([CH3:28])([CH3:27])[CH3:26])C1C=CC=CC=1>C(O)C.[Pd]>[NH2:10][C@@H:11]([CH2:40][CH2:41][NH:42][C:43]([O:45][C:46]([CH3:49])([CH3:48])[CH3:47])=[O:44])[C:12]([NH:13][CH2:14][CH2:15][CH2:16][C@@H:17]([C:18]([NH:19][CH2:20][CH2:21][NH:22][C:23]([O:24][C:25]([CH3:28])([CH3:26])[CH3:27])=[O:29])=[O:30])[NH:31][C:32]([O:34][C:35]([CH3:36])([CH3:37])[CH3:38])=[O:33])=[O:39]

Participants

4

Reactant 1

HCID 131727172HCID 131727172, compound

Product 1

HCID 86619455HCID 86619455, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

355 mg (0.5 mmol) of the compound from Example 267A are dissolved in 17 ml of ethanol, and 36 mg (0.03 mmol) of Pd/C (10%) are added. The mixture is hydrogenated under atmospheric pressure overnight and, after filtration through celite, the filtrate is concentrated in vacuo. The solid obtained in this way is reacted further without purification.

Workup

  1. customis hydrogenated under atmospheric pressure overnight
  2. filtrationafter filtration through celite
  3. concentrationthe filtrate is concentrated in vacuo
  4. customThe solid obtained in this way
  5. customis reacted further without purification

Sources & evidence

ORD record
ord-63615a8a482744e381d8d89b9825702b
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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