huagongshe.com
HRID269694

反应详情

EQUATION

反应方程式

HRID 269694 的结构方程式

REACTANTS

反应物

2
结构：Cl
HCID313

Hydrochloric Acid

ClH

结构：CC(C)(C)OC(=O)N[C@H]1Cc2cc(ccc2O)-c2ccc(O)c(c2)C[C@@H](C(=O)N[C@@H](C[C@@H](O)CN)C(=O)NCCN)NC(=O)[C@H](C[C@@H](O)CN(C(=O)O)C(C)(C)C)NC1=O.Cl.Cl
HCID86619457

未命名化合物

PRODUCTS

生成物

1
结构：Cl.Cl.Cl.Cl.NCCNC(=O)[C@H](C[C@@H](O)CN)NC(=O)[C@@H]1Cc2cc(ccc2O)-c2ccc(O)c(c2)C[C@H](N)C(=O)N[C@@H](C[C@@H](O)CN)C(=O)N1
HCID50938820

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1COCCO1
溶剂HCID31275

1,4-Dioxane

C4H8O2

2 次

CONDITIONS

反应条件

温度
0 °C

PROCEDURE

实验过程

16 mg (0.02 mmol) of the compound from Example 172A are provided in 0.5 ml of dioxane and cooled to 0° C., and 1 ml of 4N hydrogen chloride in dioxane is added. The mixture is allowed to warm to room temperature and is stirred for 1 h. The mixture is then concentrated in vacuo and the residue is dried under high vacuum. Stirring with acetonitrile and collecting the precipitate which has separated out by filtration results in the title compound as a solid.

WORKUP

后处理

  1. temperatureto warm to room temperature
  2. concentrationThe mixture is then concentrated in vacuo
  3. customthe residue is dried under high vacuum
  4. stirringStirring with acetonitrile
  5. customcollecting the precipitate which
  6. customhas separated out by filtration