Hydrochloric Acid → HCID 50940294, compound

HRID 269695Notes

Reaction equation

HRID 269695 reaction equation
C(OC(=O)[NH:7][CH2:8][CH:9]([OH:72])[CH2:10][NH:11][C:12](=[O:71])[C@@H:13]([NH:24][C:25]([C@H:27]1[NH:45][C:44](=[O:46])[C@H:43]([CH2:47][CH2:48][CH2:49][NH:50]C(OC(C)(C)C)=O)[NH:42][C:41](=[O:58])[C@@H:40]([NH:59]C(OC(C)(C)C)=O)[CH2:39][C:38]2[CH:67]=[C:34]([CH:35]=[CH:36][C:37]=2[OH:68])[C:33]2=[CH:69][C:29](=[C:30]([OH:70])[CH:31]=[CH:32]2)[CH2:28]1)=[O:26])[CH2:14][CH2:15][NH:16]C(OC(C)(C)C)=O)(C)(C)C.[ClH:74]>O1CCOCC1>[ClH:74].[ClH:74].[ClH:74].[ClH:74].[NH2:59][C@H:40]1[CH2:39][C:38]2[CH:67]=[C:34]([CH:35]=[CH:36][C:37]=2[OH:68])[C:33]2=[CH:69][C:29](=[C:30]([OH:70])[CH:31]=[CH:32]2)[CH2:28][C@@H:27]([C:25]([NH:24][C@H:13]([C:12]([NH:11][CH2:10][CH:9]([OH:72])[CH2:8][NH2:7])=[O:71])[CH2:14][CH2:15][NH2:16])=[O:26])[NH:45][C:44](=[O:46])[C@H:43]([CH2:47][CH2:48][CH2:49][NH2:50])[NH:42][C:41]1=[O:58]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 131727173HCID 131727173, compound

Product 1

HCID 50940294HCID 50940294, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

9 mg (0.01 mmol) of the compound from Example 173A are cooled to 0° C. and 1 ml of 4N hydrogen chloride in dioxane is added. After 1 h, the mixture is concentrated in vacuo. The residue is taken up in acetonitrile and again concentrated.

Workup

  1. concentrationthe mixture is concentrated in vacuo
  2. concentrationagain concentrated

Sources & evidence

ORD record
ord-224daa077ac141c882dcb649e93b5fbd
Source dataset
uspto-grants-2008_11
Patent number
US07446102B2

Reaction notes

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